Determinants of Autoantibody Induction by Conjugated Papillomavirus Virus-Like Particles

Determinants of autoantibody induction by conjugated papillomavirus virus-like particles.

Immunization of mice with self-Ag arrayed on the surface of papillomavirus-like particles induces long-lasting high-titer IgG production by autoreactive B cells. In contrast, immunization with disorganized self-Ag linked to foreign Th epitopes induces weak autoantibody responses that are predominantly of the IgM isotype. In this study, we evaluated the structural correlates of autoantibody indu...

Mucosal immunization with virus-like particles of simian immunodeficiency virus conjugated with cholera toxin subunit B.

To enhance the efficiency of antigen uptake at mucosal surfaces, CTB was conjugated to simian immunodeficiency virus (SIV) virus-like particles (VLPs). We characterized the immune responses to the Env and Gag proteins after intranasal administration. Intranasal immunization with a mixture of VLPs and CTB as an adjuvant elicited higher levels of SIV gp160-specific immunoglobulin G (IgG) in sera ...

Virus-Like Particles as a vaccinal strategy against tumors induced by papillomavirus infection

E. C. Coimbra, H. M. de Souza, M. C. G. Leitão, J. F. dos Santos, W. Beçak, R. C. Stocco dos Santos, A. C. Freitas Departamento de Genetica, Centro de Ciências Biologicas, Universidade Federal de Pernambuco, Av. Moraes Rego, s/n, 50670-901, Recife, Pernambuco, Brazil Laboratório de Genética, Instituto Butantan, Av. Vital Brazil, 1500, 05503-900, São Paulo, São Paulo, Brazil Setor de Biologia Mo...

Avian lymphoid leukosis: Virus-like particles in kidney Cells

Autoantibody Induction by DNA-Containing